Antihistamines

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Section 8 - MEDICATION GUIDELINES

8.10 ANTIHISTAMINES

Diphenhydramine (BENADRYL) / Antihistamine

DESCRIPTION

  • Inhibits the release of histamine, thereby reducing brocho-constriction and vasodilatation.

INDICATIONS

CONTRAINDICATIONS

  • Anaphylactic Shock

PRECAUTIONS

  • May induce hypotension, headache, Tachycardia, sedation, drowsiness, and /or disturbed coordination.
  • Use with caution in patients with asthma and other lower respiratory diseases due to the potential for dyspnea.

DOSAGE

  • Adult: 1 mg/ kg up to 50 mg IVP AND refer to the appropriate PRACTICE PARAMETER for specific dosages.
    • For PO administration:
      • 1 mg/kg. Currently supplied in 12.5mg/5ml.
  • Pediatrics: Refer to Handtevy System for specific dosages
    • 1 mg/kg up to 50 mg IVP
    • 1mg/kg for PO (12.5mg/5mL)


Famotidine (PEPCID) / H2 Histamine blocker

DESCRIPTION

  • Famotidine inhibits histamine at H2 receptor site in the gastric parietal cell, which inhibits gastric acid secretion.

INDICATIONS

  • Hives; Allergic reaction; Short term treatment of duodenal and gastric ulcers, management of GERD and erosive esophagitis.

CONTRAINDICATIONS

  • Hypersensitivity to the medication
  • Renal impairment

PRECAUTIONS

  • Hepatic disease, renal disease, elderly

DOSAGE

  • Currently supplied in 20mg/50 ml
  • Adults: 20mg/ 50ml given at a wide open rate.
  • Pediatrics- refer to the Handtevy System.