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Section 8 - MEDICATION GUIDELINES
SEDATIVE / HYPNOTICS / ANTIPSYCHOTIC
Ziprasidone (GEODON) / Antipsychotic
- An atypical antipsychotic acting as a dopamine antagonist that also affects other neurotransmitters to reduce psychosis and acute agitation.
- Used for the control of acute agitation in schizophrenic and/or severely agitated patients.
- Persons known to have prolonged QTc intervals
- Only in high doses of 40-60 mg has shown a slight increase in QTc
- Known recent acute myocardial infarction
- Uncompensated heart failure
- Patients known to take other medications that also prolong the QTc interval
- Hypersensitivity to the medication.
- No clinically significant drug-drug interactions have been identified with other concomitantly administered EMS medications such as benzodiazepines.
- 10 - 20 IM for adults based on the BARS scale for agitation.
- Not approved for use in pediatric patients.
ONSET OF ACTION
- Less than 15 minutes
- Peak effect 20-30 minutes
- Half-Life 2-5 hours
Behavioral Activity Rating Scale
|7||Violent, requires restraint.|
|6||Extremely/continually active; not requiring restraint.|
|5||Signs of overt (physical or verbal) activity; calms down with instruction.|
|4||Quiet and awake (normal activity level).|
|3||Drowsy, appears sedated.|
|2||Asleep, but responds normally to verbal or physical contact.|
|1||Difficult or unable to arouse.|
Medications known to prolong the QTc (This table is not all inclusive)