View source for Anti-Fibrinolytic

==Section 8 - MEDICATION GUIDELINES==
===8.19 ANTI-FIBRINOLYTICS===

====Tranexamic Acid (TXA)====

'''DESCRIPTION'''
* Inhibits both plasminogen activation and plasmin activity, thus preventing clot break-down rather than promoting new clot formation. With massive bleeding this may help stabilize clot formation and decrease extravascular bleeding.
'''INDICATIONS'''
* [[Shock|Severe Hemorrhagic Shock]].
'''CONTRAINDICATIONS'''
* Isolated head injury
* Known hypersensitivity
* Age less than 16 years old
* Known pregnancy
'''PRECAUTIONS'''
* Rapid injection can cause hypotension
'''DOSAGE'''
* 1000 mg of TXA mixed in 100 ml or 250 ml of normal saline infused via IO or IV over 10 minutes.

[[Category:Medication Guidelines|0819]]