Anti-Fibrinolytic

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Section 8 - MEDICATION GUIDELINES

8.19 ANTI-FIBRINOLYTICS

Tranexamic Acid (TXA)

DESCRIPTION

  • Inhibits both plasminogen activation and plasmin activity, thus preventing clot break-down rather than promoting new clot formation. With massive bleeding this may help stabilize clot formation and decrease extravascular bleeding.

INDICATIONS

CONTRAINDICATIONS

  • Isolated head injury
  • Known hypersensitivity
  • Age less than 16 years old
  • Known pregnancy

PRECAUTIONS

  • Rapid injection can cause hypotension

DOSAGE

  • 1000 mg of TXA mixed in 100 ml or 250 ml of normal saline infused via IO or IV over 10 minutes. Should be administered via a rate limiting device such as a Dial-A-Flo. A Buretrol is not a rate limiting device.
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