Anti-Fibrinolytic: Difference between revisions

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* Inhibits both plasminogen activation and plasmin activity, thus preventing clot break-down rather than promoting new clot formation. With massive bleeding this may help stabilize clot formation and decrease extravascular bleeding.
* Inhibits both plasminogen activation and plasmin activity, thus preventing clot break-down rather than promoting new clot formation. With massive bleeding this may help stabilize clot formation and decrease extravascular bleeding.
'''INDICATIONS'''
'''INDICATIONS'''
* [[Shock|Severe Hemorrhagic Shock]].
* [[Hemorrhagic Shock|Severe Hemorrhagic Shock]].
*Strongly consider in non-traumatic bleeding (post-partum, gastrointestinal, postoperative, nasal) 
 
'''PREGNANCY CATEGORY'''
* B - Safe in Pregnancy
* Safe in breastfeeding
 
'''CONTRAINDICATIONS'''
'''CONTRAINDICATIONS'''
* Isolated head injury
* Hypersensitivity to TXA
* Known hypersensitivity
* Colorblindness
* Age less than 16 years old
* History of Seizures
* Known pregnancy
* Ischemic event: Myocardial Infarction, stroke, pulmonary embolism (PE), deep venous thrombosis (DVT)
* Isolated head injury / subarachnoid hemorrhage
 
'''PRECAUTIONS'''
'''PRECAUTIONS'''
* Rapid injection can cause hypotension
* Rapid injection can cause hypotension
'''DOSAGE'''
'''DOSAGE'''
* 1000 mg of TXA mixed in 100 ml or 250 ml of normal saline infused via IO or IV over 10 minutes.
* 1000 mg of TXA mixed in 100 ml or 250 ml of normal saline infused via IO or IV over 10 minutes.
* 20mg/kg (1000mg maximum) TXA mixed in 100 ml of Normal Saline infused via IO or IV over 10 minutes. 


[[Category:Medication Guidelines|0819]]
[[Category:Medication Guidelines|0819]]

Latest revision as of 19:21, 10 July 2019

Section 8 - MEDICATION GUIDELINES

8.19 ANTI-FIBRINOLYTICS

Tranexamic Acid (TXA)

DESCRIPTION

  • Inhibits both plasminogen activation and plasmin activity, thus preventing clot break-down rather than promoting new clot formation. With massive bleeding this may help stabilize clot formation and decrease extravascular bleeding.

INDICATIONS

  • Severe Hemorrhagic Shock.
  • Strongly consider in non-traumatic bleeding (post-partum, gastrointestinal, postoperative, nasal)

PREGNANCY CATEGORY

  • B - Safe in Pregnancy
  • Safe in breastfeeding

CONTRAINDICATIONS

  • Hypersensitivity to TXA
  • Colorblindness
  • History of Seizures
  • Ischemic event: Myocardial Infarction, stroke, pulmonary embolism (PE), deep venous thrombosis (DVT)
  • Isolated head injury / subarachnoid hemorrhage

PRECAUTIONS

  • Rapid injection can cause hypotension

DOSAGE

  • 1000 mg of TXA mixed in 100 ml or 250 ml of normal saline infused via IO or IV over 10 minutes.
  • 20mg/kg (1000mg maximum) TXA mixed in 100 ml of Normal Saline infused via IO or IV over 10 minutes.