Cyanokit

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Section 8 - MEDICATION GUIDELINES

ANTAGONISTS

CyanoKit® (Hydroxocobalamin)

DESCRIPTION

  • CYANOKIT® Antidote is a cyanide poisoning antidote. Upon administration of CYANOKIT® Antidote, hydroxocobalamin directly binds cyanide, forming a natural form of vitamin B12, cyanocobalamin, which is excreted in the urine.

INDICATIONS

  • Cyanokit contains hydroxocobalamin, an antidote indicated for the treatment of known or suspected cyanide poisoning.

CONTRAINDICATIONS

  • Hypersensitivity to the medication.

PRECAUTIONS

  • Most common adverse reactions (>5%) include transient chromaturia, erythema, rash, increased blood pressure, nausea, headache, and injection site reactions

DOSAGE

  • The starting dose of Cyanokit for adults is 5 g, (two 2.5 g vials) administered by IV infusion over 15 minutes.
  • Depending upon the severity of the poisoning and the clinical response, a second dose of 5 g may be administered by IV infusion for a total dose of 10 g.
  • Refer to Handtevy System for pediatric specific dosages
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